Screening Coverage Needed to Reduce Mortality from Prostate Cancer: A Living Systematic Review.

ABSTRACT:

Introduction

Screening for prostate cancer remains controversial because of conflicting results from the two major trials: The Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) screening trial and the European Randomized Study of Screening for Prostate Cancer (ERSPC).

Objective

Meta-analyze and meta-regress the available PSA screening trials.

Methods

We performed a living systematic review and meta-regression of the reduction in prostate cancer mortality as a function of the duration of screening provided in each trial. We searched PubMed, Web of Science, the Cochrane Registry, and references lists from previous meta-analyses to identify randomized trials of PSA screening. We followed PRISMA guidelines and qualified strength of evidence with a GRADE Profile.

Res

SUBMITTER: Rahal AK 

PROVIDER: S-EPMC4829241 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature