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The elusive quest for RNA knots.

ABSTRACT: Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made it possible to investigate the incidence of physical knots in this type of biomolecule, too. Strikingly, no knots have been found to date in the known RNA structures. In this Point of View Article we discuss the absence of knots in currently available RNAs and consider the reasons why knots in RNA have not yet been found, despite the expectation that they should exist in Nature. We conclude by singling out a number of RNA sequences that, based on the properties of their predicted secondary structures, are good candidates for knotted RNAs.

SUBMITTER: Burton AS

PROVIDER: S-EPMC4829277 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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The elusive quest for RNA knots.

Burton Aaron S AS Burton Aaron S AS Di Stefano Marco M Lehman Niles N Orland Henri H Micheletti Cristian C

RNA biology 20160101 2

Physical entanglement, and particularly knots arise spontaneously in equilibrated polymers that are sufficiently long and densely packed. Biopolymers are no exceptions: knots have long been known to occur in proteins as well as in encapsidated viral DNA. The rapidly growing number of RNA structures has recently made it possible to investigate the incidence of physical knots in this type of biomolecule, too. Strikingly, no knots have been found to date in the known RNA structures. In this Point o ...[more]

PMID: 26828280

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