Ontology highlight
ABSTRACT:
SUBMITTER: Te Winkel JD
PROVIDER: S-EPMC4829611 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Te Winkel J Derk JD Gray Declan A DA Seistrup Kenneth H KH Hamoen Leendert W LW Strahl Henrik H
Frontiers in cell and developmental biology 20160413
The bacterial cytoplasmic membrane is a major inhibitory target for antimicrobial compounds. Commonly, although not exclusively, these compounds unfold their antimicrobial activity by disrupting the essential barrier function of the cell membrane. As a consequence, membrane permeability assays are central for mode of action studies analysing membrane-targeting antimicrobial compounds. The most frequently used in vivo methods detect changes in membrane permeability by following internalization of ...[more]