Ontology highlight
ABSTRACT:
SUBMITTER: Pule GD
PROVIDER: S-EPMC4829639 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Pule Gift D GD Mowla Shaheen S Novitzky Nicolas N Wiysonge Charles S CS Wonkam Ambroise A
Expert review of hematology 20150901 5
<h4>Aim</h4>To report on molecular mechanisms of fetal hemoglobin (HbF) induction by hydroxyurea (HU) for the treatment of sickle cell disease.<h4>Study design</h4>Systematic review.<h4>Results</h4>Studies have provided consistent associations between genomic variations in HbF-promoting loci and variable HbF level in response to HU. Numerous signal transduction pathways have been implicated, through the identification of key genomic variants in BCL11A, HBS1L-MYB, SAR1 or XmnI polymorphism that p ...[more]