Ontology highlight
ABSTRACT:
SUBMITTER: Gupta V
PROVIDER: S-EPMC4830130 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20160201 16
Concerns about off-target effects has motivated the development of reversible covalent inhibition strategies for targeting cysteine. However, such strategies have not been reported for the unique cysteine oxoform, sulfenic acid. Herein, we have designed and identified linear C-nucleophiles that react selectively with cysteine sulfenic acid. The resulting thioether adducts exhibit reversibility ranging from minutes to days under reducing conditions, showing the feasibility of tuning C-nucleophile ...[more]