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Advances in understanding - genetic basis of intellectual disability.


ABSTRACT: Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes underlying (syndromic and non-syndromic) intellectual disability, it provides a succinct analysis of their Gene Ontology, and it suggests the use of transcriptional profiling for the prioritization of candidate genes.

SUBMITTER: Chiurazzi P 

PROVIDER: S-EPMC4830215 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Advances in understanding - genetic basis of intellectual disability.

Chiurazzi Pietro P   Pirozzi Filomena F  

F1000Research 20160407


Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes  ...[more]

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