Ontology highlight
ABSTRACT:
SUBMITTER: Aslan B
PROVIDER: S-EPMC4830335 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nature communications 20150617
Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to target this process are currently available. Here, an integrative computational analysis of the Cancer Genome Atlas OC data set and experimental validation identifies a zinc finger transcription factor ZNF304 associated with OC metastasis. High tumoral ZNF304 expression is associated with poor overall survival in OC patients. Through reverse phase protein array analysis, we demonstrate that ZNF304 promotes multipl ...[more]