Notch Signaling in Neuroendocrine Tumors.
Ontology highlight
ABSTRACT:
SUBMITTER: Crabtree JS
PROVIDER: S-EPMC4830836 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Notch Signaling in Neuroendocrine Tumors.
Crabtree Judy S JS Singleton Ciera S CS Miele Lucio L
Frontiers in oncology 20160414
Carcinoids and neuroendocrine tumors (NETs) are a heterogeneous group of tumors that arise from the neuroendocrine cells of the GI tract, endocrine pancreas, and the respiratory system. NETs remain significantly understudied with respect to molecular mechanisms of pathogenesis, particularly the role of cell fate signaling systems such as Notch. The abundance of literature on the Notch pathway is a testament to its complexity in different cellular environments. Notch receptors can function as onc ...[more]
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