Ontology highlight
ABSTRACT:
SUBMITTER: Pehkonen H
PROVIDER: S-EPMC4830931 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Pehkonen Henna H von Nandelstadh Pernilla P Karhemo Piia-Riitta PR Lepikhova Tatiana T Grenman Reidar R Lehti Kaisa K Monni Outi O
Scientific reports 20160414
PPFIA1 is located at the 11q13 region, which is one of the most commonly amplified regions in several epithelial cancers including head and neck squamous cell carcinoma and breast carcinoma. Considering the location of PPFIA1 in this amplicon, we examined whether protein encoded by PPFIA1, liprin-α1, possesses oncogenic properties in relevant carcinoma cell lines. Our results indicate that liprin-α1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate fil ...[more]