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Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.

ABSTRACT: Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3'-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a ?-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.

SUBMITTER: Yan S

PROVIDER: S-EPMC4831628 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.

Yan Shanshan S Miller Marvin J MJ Wencewicz Timothy A TA Möollmann Ute U

MedChemComm 20100505 2

Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3'-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components. ...[more]

PMID: 27087912

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