Ontology highlight
ABSTRACT:
SUBMITTER: Savers A
PROVIDER: S-EPMC4831689 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Savers Amélie A Rasid Orhan O Parlato Marianna M Brock Matthias M Jouvion Gregory G Ryffel Bernhard B Cavaillon Jean-Marc JM Eberl Gerard G Ibrahim-Granet Oumaïma O
PloS one 20160414 4
Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge are protected against a secondary lethal challenge. Using RAGγc knock-out mice we show that this protection is independent of T, B and NK cells. In protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocyt ...[more]