Ontology highlight
ABSTRACT:
SUBMITTER: Chan AS
PROVIDER: S-EPMC4831889 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20160224 8
The parathyroid hormone 1 receptor (PTHR) is central to the process of bone formation and remodeling. PTHR signaling requires receptor internalization into endosomes, which is then terminated by recycling or degradation. Here we show that sorting nexin 27 (SNX27) functions as an adaptor that couples PTHR to the retromer trafficking complex. SNX27 binds directly to the C-terminal PDZ-binding motif of PTHR, wiring it to retromer for endosomal sorting. The structure of SNX27 bound to the PTHR motif ...[more]