Ontology highlight
ABSTRACT:
SUBMITTER: Miao Y
PROVIDER: S-EPMC4832064 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Miao Yansong Y Han Xuemei X Zheng Liangzhen L Xie Ying Y Mu Yuguang Y Yates John R JR Drubin David G DG
Nature communications 20160412
Actin cables, composed of actin filament bundles nucleated by formins, mediate intracellular transport for cell polarity establishment and maintenance. We previously observed that metaphase cells preferentially promote actin cable assembly through cyclin-dependent kinase 1 (Cdk1) activity. However, the relevant metaphase Cdk1 targets were not known. Here we show that the highly conserved actin filament crosslinking protein fimbrin is a critical Cdk1 target for actin cable assembly regulation in ...[more]