Ontology highlight
ABSTRACT:
SUBMITTER: Khelfa Y
PROVIDER: S-EPMC4832138 | biostudies-literature | 2016 Apr-Jun
REPOSITORIES: biostudies-literature
Journal of investigative medicine high impact case reports 20160408 2
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), representing approximately 25% of diagnosed NHL. DLBCL is heterogeneous disease both clinically and genetically. The 3 most common chromosomal translocations in DLBCL involve the oncogenes BCL2, BCL6, and MYC. Double hit (DH) DLBCL is an aggressive form in which MYC rearrangement is associated with either BCL2 or BCL6 rearrangement. Patients typically present with a rapidly growing mass, often with B sym ...[more]