Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women.
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ABSTRACT:
SUBMITTER: Wiklund P
PROVIDER: S-EPMC4832240 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women.
Wiklund Petri P Zhang Xiaobo X Pekkala Satu S Autio Reija R Kong Lingjia L Yang Yifan Y Keinänen-Kiukaanniemi Sirkka S Alen Markku M Cheng Sulin S
Scientific reports 20160415
Insulin resistance is associated adiposity, but the mechanisms are not fully understood. In this study, we aimed to identify early metabolic alterations associated with insulin resistance in normoglycemic women with varying degree of adiposity. One-hundred and ten young and middle-aged women were divided into low and high IR groups based on their median HOMA-IR (0.9 ± 0.4 vs. 2.8 ± 1.2). Body composition was assessed using DXA, skeletal muscle and liver fat by proton magnetic resonance spectrosc ...[more]
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