Ontology highlight
ABSTRACT:
SUBMITTER: Bagley AF
PROVIDER: S-EPMC4833008 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bagley Alexander F AF Scherz-Shouval Ruth R Galie Peter A PA Zhang Angela Q AQ Wyckoff Jeffrey J Whitesell Luke L Chen Christopher S CS Lindquist Susan S Bhatia Sangeeta N SN
Cancer research 20150629 16
The delivery of diagnostic and therapeutic agents to solid tumors is limited by physical transport barriers within tumors, and such restrictions directly contribute to decreased therapeutic efficacy and the emergence of drug resistance. Nanomaterials designed to perturb the local tumor environment with precise spatiotemporal control have demonstrated potential to enhance drug delivery in preclinical models. Here, we investigated the ability of one class of heat-generating nanomaterials called pl ...[more]