The dJ/dS Ratio Test Reveals Hundreds of Novel Putative Cancer Drivers.
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ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC4833070 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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The dJ/dS Ratio Test Reveals Hundreds of Novel Putative Cancer Drivers.
Chen Han H Xing Ke K He Xionglei X
Molecular biology and evolution 20150414 8
Computational tools with a balanced sensitivity and specificity in identification of candidate cancer drivers are highly desired. In this study, we propose a new statistical test, namely the dJ/dS ratio test, to compute the relative mutation rate of exon/intron junction sites (dJ) to synonymous sites (dS); observation of dJ/dS ratio larger than 1 in cancer indicates positive selection for splicing deregulation, a signature of cancer driver genes. Using this method, we analyzed the data from The ...[more]
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