Unraveling secrets of telomeres: one molecule at a time.
Ontology highlight
ABSTRACT:
SUBMITTER: Lin J
PROVIDER: S-EPMC4833095 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Unraveling secrets of telomeres: one molecule at a time.
Lin Jiangguo J Kaur Parminder P Countryman Preston P Opresko Patricia L PL Wang Hong H
DNA repair 20140222
Telomeres play important roles in maintaining the stability of linear chromosomes. Telomere maintenance involves dynamic actions of multiple proteins interacting with long repetitive sequences and complex dynamic DNA structures, such as G-quadruplexes, T-loops and t-circles. Given the heterogeneity and complexity of telomeres, single-molecule approaches are essential to fully understand the structure-function relationships that govern telomere maintenance. In this review, we present a brief over ...[more]
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