Ontology highlight
ABSTRACT:
SUBMITTER: Wright DF
PROVIDER: S-EPMC4833152 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Wright Daniel F B DF Duffull Stephen B SB Merriman Tony R TR Dalbeth Nicola N Barclay Murray L ML Stamp Lisa K LK
British journal of clinical pharmacology 20151229 2
<h4>Aims</h4>The primary aim of this research was to predict the allopurinol maintenance doses required to achieve the target plasma urate of ≤0.36 mmol l(-1) .<h4>Methods</h4>A population analysis was conducted in nonmem using oxypurinol and urate plasma concentrations from 133 gout patients. Maintenance dose predictions to achieve the recommended plasma urate target were generated.<h4>Results</h4>The urate response was best described by a direct effects model. Renal function, diuretic use and ...[more]