Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx.

ABSTRACT: Gene expression and its regulation can vary substantially across tissue types. In order to generate knowledge about gene expression in human tissues, the Genotype-Tissue Expression (GTEx) program has collected transcriptome data in a wide variety of tissue types from post-mortem donors. However, many tissue types are difficult to access and are not collected in every GTEx individual. Furthermore, in non-GTEx studies, the accessibility of certain tissue types greatly limits the feasibility and scale of studies of multi-tissue expression. In this work, we developed multi-tissue imputation methods to impute gene expression in uncollected or inaccessible tissues. Via simulation studies, we showed that the proposed methods outperform existing imputation methods in multi-tissue expression imputa

SUBMITTER: Wang J 

PROVIDER: S-EPMC4833292 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature