Precision Medicine: Personalized Proteomics for the Diagnosis and Treatment of Idiopathic Inflammatory Disease.
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ABSTRACT:
SUBMITTER: Velez G
PROVIDER: S-EPMC4833518 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Precision Medicine: Personalized Proteomics for the Diagnosis and Treatment of Idiopathic Inflammatory Disease.
Velez Gabriel G Roybal C Nathaniel CN Colgan Diana D Tsang Stephen H SH Bassuk Alexander G AG Mahajan Vinit B VB
JAMA ophthalmology 20160401 4
<h4>Importance</h4>To better characterize posterior uveitis, vitreous samples from 15 patients were subjected to antibody arrays, and the expression levels of 200 human cytokines were evaluated. Expression was analyzed by 1-way analysis of variance (significance at P < .01), unsupervised cluster algorithm, and pathway analysis.<h4>Observations</h4>Unbiased clustering of patients, based on their cytokine expression profile, suggested that particular protein networks and molecular pathways are alt ...[more]
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