Ontology highlight
ABSTRACT:
SUBMITTER: Kim MM
PROVIDER: S-EPMC4833892 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Kim Michelle M MM Parmar Hemant H Cao Yue Y Pramanik Priyanka P Schipper Matthew M Hayman James J Junck Larry L Mammoser Aaron A Heth Jason J Carter Corey A CA Oronsky Arnold A Knox Susan J SJ Caroen Scott S Oronsky Bryan B Scicinski Jan J Lawrence Theodore S TS Lao Christopher D CD
Translational oncology 20160401 2
<h4>Background</h4>Kim et al. report two patients with melanoma metastases to the brain that responded to treatment with RRx-001 and whole brain radiotherapy (WBRT) without neurologic or systemic toxicity in the context of a phase I/II clinical trial. RRx-001 is an reactive oxygen and reactive nitrogen species (ROS/RNS)-dependent systemically nontoxic hypoxic cell radiosensitizer with vascular normalizing properties under investigation in patients with various solid tumors including those with b ...[more]