New encouraging developments in contact prediction: Assessment of the CASP11 results.

ABSTRACT: This article provides a report on the state-of-the-art in the prediction of intra-molecular residue-residue contacts in proteins based on the assessment of the predictions submitted to the CASP11 experiment. The assessment emphasis is placed on the accuracy in predicting long-range contacts. Twenty-nine groups participated in contact prediction in CASP11. At least eight of them used the recently developed evolutionary coupling techniques, with the top group (CONSIP2) reaching precision of 27% on target proteins that could not be modeled by homology. This result indicates a breakthrough in the development of methods based on the correlated mutation approach. Successful prediction of contacts was shown to be practically helpful in modeling three-dimensional structures; in particular target T

SUBMITTER: Monastyrskyy B 

PROVIDER: S-EPMC4834069 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature