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Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients.

ABSTRACT: Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated.In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-sectional relationships of polypharmacy (?5 medications concomitantly used), severe polypharmacy (?10 medications), and use of twenty-one specific drug groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance.Overall prevalence of polypharmacy was 65 %, of severe polypharmacy 22 %. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 % (<50 nmol/l) or 77 % (<75 nmol/l). Of the patients using a vitamin D supplement, 17 % (<50 nmol/l) or 49 % (<75 nmol/l) were still deficient. In non-users of supplemental vitamin D, after adjustment for age and gender, negative associations were found for severe polypharmacy, metformin, sulphonamides and urea derivatives (SUDs), vitamin K antagonists, cardiac glycosides, loop diuretics, potassium-sparing diuretics, ACE inhibitors, and serotonin reuptake inhibitors; for non-selective monoamine reuptake inhibitors (NSMRIs) the association was positive. The most extreme impacts of drug use on adjusted mean 25(OH)D were -19 nmol/l for SUDs and +18 nmol/l for NSMRIs.Drug use should be considered a risk factor for vitamin D deficiency amongst geriatric outpatients.

SUBMITTER: van Orten-Luiten AC

PROVIDER: S-EPMC4834096 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients.

van Orten-Luiten A C B AC Janse A A Dhonukshe-Rutten R A M RA Witkamp R F RF

European journal of clinical pharmacology 20160212 5

<h4>Purpose</h4>Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated.<h4>Methods</h4>In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-section ...[more]

PMID: 26873590

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Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients.

Publications

Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients.

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