Ontology highlight
ABSTRACT:
SUBMITTER: Cheng J
PROVIDER: S-EPMC4834193 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cheng Jianjun J Giguère Patrick M PM Onajole Oluseye K OK Lv Wei W Gaisin Arsen A Gunosewoyo Hendra H Schmerberg Claire M CM Pogorelov Vladimir M VM Rodriguiz Ramona M RM Vistoli Giulio G Wetsel William C WC Roth Bryan L BL Kozikowski Alan P AP
Journal of medicinal chemistry 20150210 4
The discovery of a new series of compounds that are potent, selective 5-HT2C receptor agonists is described herein as we continue our efforts to optimize the 2-phenylcyclopropylmethylamine scaffold. Modifications focused on the alkoxyl substituent present on the aromatic ring led to the identification of improved ligands with better potency at the 5-HT2C receptor and excellent selectivity against the 5-HT2A and 5-HT2B receptors. ADMET studies coupled with a behavioral test using the amphetamine- ...[more]