Thiol-ene Photocrosslinking of Cytocompatible Resilin-Like Polypeptide-PEG Hydrogels.
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ABSTRACT:
SUBMITTER: McGann CL
PROVIDER: S-EPMC4834209 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Thiol-ene Photocrosslinking of Cytocompatible Resilin-Like Polypeptide-PEG Hydrogels.
McGann Christopher L CL Dumm Rebekah E RE Jurusik Anna K AK Sidhu Ishnoor I Kiick Kristi L KL
Macromolecular bioscience 20151005 1
A range of chemical strategies have been used for crosslinking recombinant polypeptide hydrogels, although only a few have employed photocrosslinking approaches. Here, we capitalize on the novel insect protein, resilin, and the versatility of click reactions to introduce a resilin-like polypeptide (RLP) that is capable of photoinitiated thiol-ene crosslinking. Lysine residues of the RLP were functionalized with norbornene acid as confirmed via 1H-NMR spectroscopy. The RLPNs were subsequently pho ...[more]
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