MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
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ABSTRACT:
SUBMITTER: Moore CE
PROVIDER: S-EPMC4834573 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
Moore C E J CE Pickford J J Cagampang F R FR Stead R L RL Tian S S Zhao X X Tang X X Byrne C D CD Proud C G CG
Scientific reports 20160418
The MAP kinase-interacting kinases (MNK1 and MNK2) are non-essential enzymes which are activated by MAP kinases. They are implicated in controlling protein synthesis. Here we show that mice in which the expression of either MNK1 or MNK2 has been knocked out (KO) are protected against adverse effects of high-fat feeding, and in distinct ways. High-fat diet (HFD)-fed MNK2-KO show less weight gain than wild-type animals, and improved glucose tolerance, better insulin sensitivity and markedly dimini ...[more]
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