Stacking with No Planarity?
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ABSTRACT:
SUBMITTER: Gunaydin H
PROVIDER: S-EPMC4834644 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Stacking with No Planarity?
Gunaydin Hakan H Bartberger Michael D MD
ACS medicinal chemistry letters 20160406 4
This viewpoint describes the results obtained from matched molecular pair analyses and quantum mechanics calculations that show unsaturated rings found in drug-like molecules may be replaced with their saturated counterparts without losing potency even if they are engaged in stacking interactions with the side chains of aromatic residues. ...[more]
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