Ontology highlight
ABSTRACT:
SUBMITTER: Cee VJ
PROVIDER: S-EPMC4834646 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20160212 4
The identification of Pim-1/2 kinase overexpression in B-cell malignancies suggests that Pim kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple myeloma. Starting from a moderately potent quinoxaline-dihydropyrrolopiperidinone lead, we recognized the potential for macrocyclization and developed a series of 13-membered macrocycles. The structure-activity relationships of the macrocyclic linker were systematically explored, leading to the identification of 9c a ...[more]