Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.
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ABSTRACT:
SUBMITTER: Gyongyosi M
PROVIDER: S-EPMC4834852 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.
Gyöngyösi Mariann M Wojakowski Wojciech W Navarese Eliano P EP Moye Lemuel À LÀ
Circulation research 20160401 8
In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfa ...[more]
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