Ontology highlight
ABSTRACT:
SUBMITTER: Panaccione A
PROVIDER: S-EPMC4834904 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Panaccione Alex A Chang Michael T MT Carbone Beatrice E BE Guo Yan Y Moskaluk Christopher A CA Virk Renu K RK Chiriboga Luis L Prasad Manju L ML Judson Benjamin B Mehra Saral S Yarbrough Wendell G WG Ivanov Sergey V SV
Clinical cancer research : an official journal of the American Association for Cancer Research 20160401 8
<h4>Purpose</h4>Although the existence of cancer stem cells (CSC) in adenoid cystic carcinoma (ACC) has been proposed, lack of assays for their propagation and uncertainty about molecular markers prevented their characterization. Our objective was to isolate CSC from ACC and provide insight into signaling pathways that support their propagation.<h4>Experimental design</h4>To isolate CSC from ACC and characterize them, we used ROCK inhibitor-supplemented cell culture, immunomagnetic cell sorting, ...[more]