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Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent.

ABSTRACT: The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17.

SUBMITTER: Noor Z

PROVIDER: S-EPMC4835063 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent.

Noor Zannatun Z Burgess Stacey L SL Watanabe Koji K Petri William A WA

PloS one 20160418 4

The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream o ...[more]

PMID: 27089535

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