Ontology highlight
ABSTRACT:
SUBMITTER: Awan FT
PROVIDER: S-EPMC4835239 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Awan Farrukh T FT Flynn Joseph M JM Jones Jeffrey A JA Andritsos Leslie A LA Maddocks Kami J KJ Sass Ellen J EJ Lucas Margaret S MS Chase Weihong W Waymer Sharon S Ling Yonghua Y Jiang Yao Y Phelps Mitch A MA Byrd John C JC Lucas David M DM Woyach Jennifer A JA
Leukemia & lymphoma 20150311 10
The proteasome complex degrades proteins involved in a variety of cellular processes and is a powerful therapeutic target in several malignancies. Carfilzomib is a potent proteasome inhibitor which induces rapid chronic lymphocytic leukemia (CLL) cell apoptosis in vitro. We conducted a phase I dose-escalation trial to determine the safety and tolerability of carfilzomib in relapsed/refractory CLL or small lymphocytic lymphoma (SLL). Nineteen patients were treated with carfilzomib initially at 20 ...[more]