Dataset Information

Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia.

ABSTRACT:

Study objectives

Although daytime complaints are a defining characteristic of insomnia, most EEG studies evaluated sleep only. We used high-density electroencephalography to investigate wake resting state oscillations characteristic of insomnia disorder (ID) at a fine-grained spatiospectral resolution.

Methods

A case-control assessment during eyes open (EO) and eyes closed (EC) was performed in a laboratory for human physiology. Participants (n = 94, 74 female, 21-70 y) were recruited through www.sleepregistry.nl: 51 with ID, according to DSM-5 and 43 matched controls. Exclusion criteria were any somatic, neurological or psychiatric condition. Group differences in the spectral power topographies across multiple frequencies (1.5 to 40 Hz) were evaluated using permutation-based inference with Threshold-Free Cluster-Enhancement, to correct for multiple comparisons.

Results

As compared to controls, participants with ID showed less power in a narrow upper alpha band (11-12.7 Hz, peak: 11.7 Hz) over bilateral frontal and left temporal regions during EO, and more power in a broad beta frequency range (16.3-40 Hz, peak: 19 Hz) globally during EC. Source estimates suggested global rather than cortically localized group differences.

Conclusions

The widespread high power in a broad beta band reported previously during sleep in insomnia is present as well during eyes closed wakefulness, suggestive of a round-the-clock hyperarousal. Low power in the upper alpha band during eyes open is consistent with low cortical inhibition and attentional filtering. The fine-grained HD-EEG findings suggest that, while more feasible than PSG, wake EEG of short duration with a few well-chosen electrodes and frequency bands, can provide valuable features of insomnia.

SUBMITTER: Colombo MA

PROVIDER: S-EPMC4835299 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia.

Colombo Michele A MA Ramautar Jennifer R JR Wei Yishul Y Gomez-Herrero Germán G Stoffers Diederick D Wassing Rick R Benjamins Jeroen S JS Tagliazucchi Enzo E van der Werf Ysbrand D YD Cajochen Christian C Van Someren Eus J W EJ

Sleep 20160501 5

<h4>Study objectives</h4>Although daytime complaints are a defining characteristic of insomnia, most EEG studies evaluated sleep only. We used high-density electroencephalography to investigate wake resting state oscillations characteristic of insomnia disorder (ID) at a fine-grained spatiospectral resolution.<h4>Methods</h4>A case-control assessment during eyes open (EO) and eyes closed (EC) was performed in a laboratory for human physiology. Participants (n = 94, 74 female, 21-70 y) were recru ...[more]

PMID: 26951395

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Dataset Information

Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia.

Study objectives

Methods

Results

Conclusions

Publications

Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia.

Similar Datasets

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