The Relationship between Sleep Quality and Brain Amyloid Burden.

ABSTRACT: To evaluate the association between self-reported sleep quality and levels of brain ?-amyloid (A?) burden, and to determine the effect of the apolipoprotein E (APOE) ?4 allele on any associations found.This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent A? positron emission tomography imaging for the quantification of brain A? burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain A? burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ?4 carriage entered as a moderator.Of the sleep factors, longer sleep latency was associated with higher levels of brain A? (B = 0.003 [standard error = 0.001], P = 0.02). APOE ?4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain A? burden.Our findings suggest a relationship between brain A? burden and sleep latency, independent of APOE ?4 genotype.

SUBMITTER: Brown BM 

PROVIDER: S-EPMC4835305 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature