An Examination of Methodological Paradigms for Calculating Upper Airway Critical Pressures during Sleep.

ABSTRACT:

Study objectives

The goal of this study was to examine different paradigms for determining critical closing pressures (Pcrit). Methods of determining Pcrit were compared, including direct observation of occluded (no flow) breaths versus inferring Pcrit from extrapolated data, and Pcrit generated by aggregating pressure-flow data from multiple runs versus Pcrit averaged across individual pressure-flow runs. The relationship between Pcrit and obstructive sleep apnea (OSA) was examined.

Methods

A total of 351 participants with and without OSA underwent overnight polysomnography with pressure-flow measurements to determine Pcrit. A series of filters were applied to raw data to provide consistent, objective criteria for determining which data to include in Pcrit calculations. Obs

SUBMITTER: Pien GW 

PROVIDER: S-EPMC4835319 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature