Ontology highlight
ABSTRACT:
SUBMITTER: Papageorgiou GK
PROVIDER: S-EPMC4835543 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Papageorgiou Georgios K GK Baudonnat Mathieu M Cucca Flavia F Walton Mark E ME
Cell reports 20160331 2
Mesolimbic dopamine encodes the benefits of a course of action. However, the value of an appetitive reward depends strongly on an animal's current state. To investigate the relationship between dopamine, value, and physiological state, we monitored sub-second dopamine release in the nucleus accumbens core while rats made choices between food and sucrose solution following selective satiation on one of these reinforcers. Dopamine signals reflected preference for the reinforcers in the new state, ...[more]