Ontology highlight
ABSTRACT:
SUBMITTER: Petaja EM
PROVIDER: S-EPMC4835723 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Petäjä Elina M EM Zhou You Y Havana Marika M Hakkarainen Antti A Lundbom Nina N Ihalainen Jarkko J Yki-Järvinen Hannele H
Scientific reports 20160419
Insulin-like growth factor binding protein 1 (IGFBP-1) is a potentially interesting marker for liver fat in NAFLD as it is exclusively produced by the liver, and insulin is its main regulator. We determined whether measurement of fasting serum phosphorylated IGFBP-1 (fS-pIGFBP-1) helps to predict liver fat compared to routinely available clinical parameters and PNPLA3 genotype at rs738409. Liver fat content (proton magnetic resonance spectroscopy) was measured in 378 subjects (62% women, age 43 ...[more]