Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez AE
PROVIDER: S-EPMC4836015 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Rodríguez Andrea E AE López-Crisosto Camila C Peña-Oyarzún Daniel D Salas Daniela D Parra Valentina V Quiroga Clara C Morawe Tobias T Chiong Mario M Behl Christian C Lavandero Sergio S
Autophagy 20160101 2
Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 or ATG12. However, little is known about the regulation of ATG protein synthesis at the translational level. The cochaperone of the HSP70 system BAG3 (BCL2-associated athanogene 3) has been associated to LC3B lipidation through an unknown mechanism. In the present work, we stu ...[more]