Ontology highlight
ABSTRACT:
SUBMITTER: Lamarthee B
PROVIDER: S-EPMC4836046 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lamarthée Baptiste B Malard Florent F Saas Philippe P Mohty Mohamad M Gaugler Béatrice B
Frontiers in immunology 20160419
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential curative treatment for hematologic malignancies and non-malignant diseases. Because of the lower toxicity of reduced intensity conditioning, the number of transplants is in constant increase. However, allo-HSCT is still limited by complications, such as graft-versus-host disease (GVHD), which is associated with important morbidity and mortality. Acute GVHD is an exacerbated inflammatory response that leads to the destr ...[more]