Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC4836277 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Chen Xu X D'Arcy Sheena S Radebaugh Catherine A CA Krzizike Daniel D DD Giebler Holli A HA Huang Liangquan L Nyborg Jennifer K JK Luger Karolin K Stargell Laurie A LA
Molecular and cellular biology 20160331 8
Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 on chromatin structure and histone dynamics during distinct transcriptional states. When the GAL locus is not expressed, cells lacking Nap1 show an accumulation of histone H2A-H2B but not histone H3-H4 at this locus. Excess H2A-H2B interacts with the linker DNA between nucleoso ...[more]