Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors.
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ABSTRACT:
SUBMITTER: Lee DW
PROVIDER: S-EPMC4836364 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
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Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors.
Lee Donald W DW Allison Andrew B AB Bacon Kaitlyn B KB Parrish Colin R CR Daniel Susan S
Journal of virology 20160414 9
Determining how viruses infect new hosts via receptor-binding mechanisms is important for understanding virus emergence. We studied the binding kinetics of canine parvovirus (CPV) variants isolated from raccoons-a newly recognized CPV host-to different carnivore transferrin receptors (TfRs) using single-particle tracking. Our data suggest that CPV may utilize adhesion-strengthening mechanisms during TfR binding and that a single mutation in the viral capsid at VP2 position 300 can profoundly alt ...[more]
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