Ontology highlight
ABSTRACT:
SUBMITTER: Lee DW
PROVIDER: S-EPMC4836364 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Journal of virology 20160414 9
Determining how viruses infect new hosts via receptor-binding mechanisms is important for understanding virus emergence. We studied the binding kinetics of canine parvovirus (CPV) variants isolated from raccoons-a newly recognized CPV host-to different carnivore transferrin receptors (TfRs) using single-particle tracking. Our data suggest that CPV may utilize adhesion-strengthening mechanisms during TfR binding and that a single mutation in the viral capsid at VP2 position 300 can profoundly alt ...[more]