Ontology highlight
ABSTRACT:
SUBMITTER: Alhusaini N
PROVIDER: S-EPMC4836645 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Alhusaini Najwa N Coller Jeff J
RNA (New York, N.Y.) 20160307 5
Decay of mRNA is essential for the efficient regulation of gene expression. A major pathway of mRNA degradation is initiated by the shortening of the poly(A) tail via the CCR4/NOT deadenylase complex. Deadenylation is followed by removal of the 5' cap (i.e., decapping) and then 5' to 3' exonucleolytic decay of the message body. The highly conserved CCR4/NOT deadenylase complex consists of the exonucleases CCR4 and POP2/CAF1, as well as a group of four or five (depending on organism) accessory fa ...[more]