Ontology highlight
ABSTRACT:
SUBMITTER: Iakovleva I
PROVIDER: S-EPMC4836675 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Iakovleva Irina I Begum Afshan A Brännström Kristoffer K Wijsekera Alexandra A Nilsson Lina L Zhang Jin J Andersson Patrik L PL Sauer-Eriksson A Elisabeth AE Olofsson Anders A
PloS one 20160419 4
Amyloid formation of the human plasma protein transthyretin (TTR) is associated with several human disorders, including familial amyloidotic polyneuropathy (FAP) and senile systemic amyloidosis. Dissociation of TTR's native tetrameric assembly is the rate-limiting step in the conversion into amyloid, and this feature presents an avenue for intervention because binding of an appropriate ligand to the thyroxin hormone binding sites of TTR stabilizes the native tetrameric assembly and impairs conve ...[more]