The Ancient Evolutionary History of Polyomaviruses.
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ABSTRACT:
SUBMITTER: Buck CB
PROVIDER: S-EPMC4836724 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
The Ancient Evolutionary History of Polyomaviruses.
Buck Christopher B CB Van Doorslaer Koenraad K Peretti Alberto A Geoghegan Eileen M EM Tisza Michael J MJ An Ping P Katz Joshua P JP Pipas James M JM McBride Alison A AA Camus Alvin C AC McDermott Alexa J AJ Dill Jennifer A JA Delwart Eric E Ng Terry F F TF Farkas Kata K Austin Charlotte C Kraberger Simona S Davison William W Pastrana Diana V DV Varsani Arvind A
PLoS pathogens 20160419 4
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billi ...[more]
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