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Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women.


ABSTRACT: BACKGROUND:Menarche is a critical time point for diverging fates of mammary cells of origin. African American women have young age at menarche, which could be associated with their high rates of estrogen receptor-negative (ER-) breast cancer. METHODS:In the AMBER Consortium, using harmonized data from 4426 African American women with breast cancer and 17 474 controls, we used polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for ages at menarche and first live birth (FLB), and the interval between, in relation to ER+ and ER- breast cancer. All statistical tests were two-sided. RESULTS:Risk of ER- breast cancer was reduced with later age at menarche among both parous and nulliparous women (?15 vs <11 years OR = 0.62, 95% CI = 0.48 to 0.81 and OR = 0.56, 95% CI = 0.29 to 1.10, respectively), with no effect of age at FLB. For ER+ breast cancer, the inverse association was weaker among nulliparous women. While longer intervals between menarche and FLB were associated with increased risk of ER+ breast cancer in a dose-response fashion (OR for 20 year interval = 1.39, 95% CI = 1.08 to 1.79, P trend = .003), ER- risk was only increased for intervals up to 14 years and not beyond (P trend = .33). CONCLUSIONS:While ER- breast cancer risk was markedly reduced in women with a late age at menarche, there was not a clear pattern of increased risk with longer interval between menarche and FLB, as was observed for ER+ breast cancer. These findings indicate that etiologic pathways involving adolescence and pregnancy may differ for ER- and ER+ breast cancer.

SUBMITTER: Ambrosone CB 

PROVIDER: S-EPMC4836800 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women.

Ambrosone Christine B CB   Zirpoli Gary G   Hong Chi-Chen CC   Yao Song S   Troester Melissa A MA   Bandera Elisa V EV   Schedin Pepper P   Bethea Traci N TN   Borges Virginia V   Park Song-Yi SY   Chandra Dhyan D   Rosenberg Lynn L   Kolonel Laurence N LN   Olshan Andrew F AF   Palmer Julie R JR  

Journal of the National Cancer Institute 20150617 9


<h4>Background</h4>Menarche is a critical time point for diverging fates of mammary cells of origin. African American women have young age at menarche, which could be associated with their high rates of estrogen receptor-negative (ER-) breast cancer.<h4>Methods</h4>In the AMBER Consortium, using harmonized data from 4426 African American women with breast cancer and 17 474 controls, we used polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for ages a  ...[more]

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