Ontology highlight
ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC4836858 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Wu Song S Powers Scott S Zhu Wei W Hannun Yusuf A YA
Nature 20151216 7584
Recent research has highlighted a strong correlation between tissue-specific cancer risk and the lifetime number of tissue-specific stem-cell divisions. Whether such correlation implies a high unavoidable intrinsic cancer risk has become a key public health debate with the dissemination of the 'bad luck' hypothesis. Here we provide evidence that intrinsic risk factors contribute only modestly (less than ~10-30% of lifetime risk) to cancer development. First, we demonstrate that the correlation b ...[more]