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Polysaccharide Extracted from Laminaria japonica Delays Intrinsic Skin Aging in Mice.


ABSTRACT: This study aimed to determine the effect of topically applied Laminaria polysaccharide (LP) on skin aging. We applied ointment containing LP (10, 25, and 50??g/g) or vitamin E (10??g/g) to the dorsal skin of aging mice for 12 months and young control mice for 4 weeks. Electron microscopy analysis of skin samples revealed that LP increased dermal thickness and skin collagen content. Tissue inhibitor of metalloprotease- (TIMP-) 1 expression was upregulated while that of matrix metalloproteinase- (MMP-) 1 was downregulated in skin tissue of LP-treated as compared to untreated aging mice. Additionally, phosphorylation of c-Jun N-terminal kinase (JNK) and p38 was higher in aging skin than in young skin, while LP treatment suppressed phospho-JNK expression. LP application also enhanced the expression of antioxidative enzymes in skin tissue, causing a decrease in malondialdehyde levels and increases in superoxide dismutase, catalase, and glutathione peroxidase levels relative to those in untreated aging mice. These results indicate that LP inhibits MMP-1 expression by preventing oxidative stress and JNK phosphorylation, thereby delaying skin collagen breakdown during aging.

SUBMITTER: Hu L 

PROVIDER: S-EPMC4837268 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Polysaccharide Extracted from Laminaria japonica Delays Intrinsic Skin Aging in Mice.

Hu Longyuan L   Tan Jia J   Yang Xiaomei X   Tan Haitao H   Xu Xiaozhen X   You Manhang M   Qin Wu W   Huang Liangzhao L   Li Siqi S   Mo Manqiu M   Wei Huifen H   Li Jing J   Tan Jiyong J  

Evidence-based complementary and alternative medicine : eCAM 20160406


This study aimed to determine the effect of topically applied Laminaria polysaccharide (LP) on skin aging. We applied ointment containing LP (10, 25, and 50 μg/g) or vitamin E (10 μg/g) to the dorsal skin of aging mice for 12 months and young control mice for 4 weeks. Electron microscopy analysis of skin samples revealed that LP increased dermal thickness and skin collagen content. Tissue inhibitor of metalloprotease- (TIMP-) 1 expression was upregulated while that of matrix metalloproteinase- (  ...[more]

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