Ontology highlight
ABSTRACT:
SUBMITTER: Imai R
PROVIDER: S-EPMC4837362 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20160420
Chromatin DNA must be read out for various cellular functions, and copied for the next cell division. These processes are targets of many anticancer agents. Platinum-based drugs, such as cisplatin, have been used extensively in cancer chemotherapy. The drug-DNA interaction causes DNA crosslinks and subsequent cytotoxicity. Recently, it was reported that an azolato-bridged dinuclear platinum(II) complex, 5-H-Y, exhibits a different anticancer spectrum from cisplatin. Here, using an interdisciplin ...[more]