Ontology highlight
ABSTRACT:
SUBMITTER: Romano O
PROVIDER: S-EPMC4837375 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Romano Oriana O Peano Clelia C Tagliazucchi Guidantonio Malagoli GM Petiti Luca L Poletti Valentina V Poletti Valentina V Cocchiarella Fabienne F Rizzi Ermanno E Severgnini Marco M Cavazza Alessia A Rossi Claudia C Pagliaro Pasqualepaolo P Ambrosi Alessandro A Ferrari Giuliana G Bicciato Silvio S De Bellis Gianluca G Mavilio Fulvio F Miccio Annarita A
Scientific reports 20160420
Genome-wide approaches allow investigating the molecular circuitry wiring the genetic and epigenetic programs of human somatic stem cells. Hematopoietic stem/progenitor cells (HSPC) give rise to the different blood cell types; however, the molecular basis of human hematopoietic lineage commitment is poorly characterized. Here, we define the transcriptional and epigenetic profile of human HSPC and early myeloid and erythroid progenitors by a combination of Cap Analysis of Gene Expression (CAGE), ...[more]